PERANAN BAHAN ALAM DALAM PANDEMI COVID-19

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Published: Jul 7, 2021
DOI: https://doi.org/10.24912/ep.v27i1.12162
Keywords:
COVID-19 natural ingredients turmeric ginger guava meniran sambiloto

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Fenny Yunita
Fakultas Kedokteran Universitas Tarumanagara

Abstract

life. Various countries have used natural materials in dealing with the COVID-19 pandemic, such as China and Thailand. Indonesia has great potential in the development of natural ingredients considering that the nation's cultural heritage has been passed down from generation to generation in the form of herbal medicine which has also been equipped with various in vitro and in vivo studies as well as molecular docking, proving opportunities for developing natural materials as one of the modalities that can be utilized to overcome the COVID-19 pandemic. Some of them are turmeric/ginger, ginger, guava, meniran, sambiloto which have also been recommended in the guidelines for the use of herbs in dealing with COVID-19 in Indonesia.

Article Details

Issue
Vol. 27 No. 1 (2021): EBERS PAPYRUS
Section
Tinjauan Pustaka
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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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Author Biography

Fenny Yunita, Fakultas Kedokteran Universitas Tarumanagara

Bagian Ilmu Farmakologi

References

BPOM RI., Pedoman Penggunaan Herbal dan Suplemen Kesehatan dalam menghadapi COVID-19 di Indonesia, 2020 : 1-123.

Kemenkes RI., Pedoman Pencegahan dan Pengendalian COVID-19. Germas, 2020 : 1-115.

Dewi,Y.K., Riyandari, B.A., Potensi Tanaman Lokal sebagai Tanaman Obat dalam Menghambat Penyebaran COVID-19. Jurnal Pharmascience 2020, 07: 112-128.

Kanyinda, J.N.M., Preparation of Papers for European Journal of Medical and Health Sciences. EJMED 2020, 2 : 1-4.

Hartanti, D., Dhiani B.A., Charisma S.L., Wahyuningrumet, R., The Potential Roles of Jamu for COVID-19 : A Learn from the Traditional Chinese Medicine. Phar Sci Res 2020, 7 : 12-23

PDPI, PERKI, PAPDI, PERDATIN, IDAI, Pedoman Tatalaksana COVID-19. 2020, 2 : 1-101.

Kementerian Kesehatan RI, 2020, Situasi Terkini Perkembangan Novel Coronavirus (COVID-19). https://covid19.kemkes.go.id/situasiinfeksi-emerging/info-coronavirus/situasi-terkini-perkembangancoronavirus-disease-covid-19-15- juli-2020/#.XxEzR2YRWMo (diakses 15 Juli 2020).

World Health Organization, 2020. Coronavirus Disease (COVID-19): Situastion report-177. https://www.who.int/emergencies/di seases/novel-coronavirus.2019/situation-reports (diakses 15 Juli 2020).

Galen, E. Van., Kroes, B., Garcia-Llorente, G., Assessment report on Curcuma longa L. rhizome-EMA/HMPC/749518/2016., European Medicines Agency- Committee on Herbal Medicinal Products (HMPC) , 2018 : 1-34.

Qaiser, D., Srivastava, A. and Qaiser, A., 2018, Anticancer Herbs for Improving the Quality of Life. International Annals of Science,2018, 5(1) : 1-11.

Galen, E. Van., Kroes, B., Assessment report on Curcuma xantorrhiza Roxb. (C. xantorrhiza D. Dietrich), rhizome. European Medicines Agency, 2014, 44 : 2

Rajkumari & Sanatombi. Nutritional value , phytochemical composition, and biological activities of edible Curcuma species : A review. International Journal of Food Properties, 2018 , 20 : 2668-2687.

Gangal, N., Nagle, V., Pawar, Y. and Dasgupta, S., Reconsidering Traditional Medicinal Plants to Combat COVID-19. AIJR Preprints, 2020 Apr, 34 : 1-6.

Das, M., Banerji, A., Cheemalapati, V.N. and Hazra, J., 2020. Antiviral Activity Of Indian Medicinal Plants: Prventive Measures For COVID-19. Journal of Global Biosciences, 2020, 9(5) : 7307-7319.

Chen, D.Y., Shien, J.H., Tiley, L., Chiou, S.S., Wang, S.Y., Chang, T.J., Lee, Y.J., Chan, K.W. and Hsu, W.L., Curcumin Inhibits Influenza Virus Infection and Haemagglutination Activity. Food Chemistry, 2010, 119(4) : 1346- 1351

Jena, A.B., Kanungo, N., Nayak, V., Chainy, G.B.N. and Dandapat, J., Catechin and Curcumin Interact With Corona (2019- nCoV/SARS-CoV2) Viral S Protein and ACE2 of Human Cell Membrane: Insights From Computational Study and Implication for Intervention. Preprint : Nature Research., 2020

Pawitan, J.A., Curcumin as Adjuvant Therapy in COVID-19: Friend or Foe?. Journal of International Dental and Medical Research, 2020, 13(2) : 824-829.

WHO., WHO Monographs on Selected Medicinal Plants volume I. 1999

Nur, Y., Cahyoutomo, A., Nanda, N. and Fistoro, N., Profil GC-MS Senyawa Metabolit Sekunder dari Jahe Merah (Zingiber officinale) dengan Metode Ekstraksi Etil Asetat, Etanol dan Destilasi. Jurnal Sains dan Kesehatan, 2020, 2(3) : 198- 204.

Kaushik, S., Jangra, G., Kundu, V., Yadav, J.P. and Kaushik, S., Anti-viral Activity of Zingiber officinale (Ginger) Ingredients Against The Chikungunya Virus. Virus Disease, 2020 May, 5 : 1-7.

Ukeh, D.A., Birkett, M.A., Pickett, J.A., Bowman, A.S. and Mordue, A.J., 2009, Repellent Activity of Alligator pepper, Aframomum melegueta, and Ginger, Zingiber officinale, Against The Maize Weevil, Sitophilus zeamais. Phytochemistry, 2009, 70(6): 751-758.

Carrasco, et al. , Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. , Syzygium aromaticum L., essential oils : evidence for humor- and cell- mediated responses. Journal of Pharmacy and Pharmacology, 2009, 61 : 961-967.

Ezzat, S. M., Ezzat, M. I., Okba, M. M., Menze, E.T., Abdel-Naim, A.B., The hidden mechanism beyond ginger (Zingiber officinale Rosc) potent in vivo and in vitro anti-inflammatory activity. Journal of Ethnopharmacology, 2018 , 214 : 113-123.

Dhanasekaran, S. and Pradeep P.S., Scope Of Phytotherapeutics In Targeting ACE2 Mediated HostViral Interface of SARS?CoV2 That Causes COVID-19. Preprint: ChemRxiv, 2020.

Ahkam, A. H., Hermanto, F.E., Alamsyah A., Aliyyah I.H., and Fatchiyah F., Virtual prediction of antiviral potential of ginger (Zingiber officinale) bioactive compounds against spike and MPro of SARS-CoV2. Journal of Biological Researches, 2020, 25(2) : 52–57.

Rajapaksa, R.M.H., Perera, B.T., Nisansala, M.J., Perera, W.P.R.T. and Dissanayake, K.G.C., Potential Of Inhibiting The Receptor Binding Mechanism Of SARSCOV2 Using Phytochemical Extracts Of Medicinal Herb; Moleculer Docking Study. Global Journal of Engineering Science and Research Management, 2020, 7(4): 51-61.

Bager, S., Assessment Report on Zingiber officinale Roscoe Rhizoma. Committee on Herbal Medicinal Products (HMPC), 2012 : 44

Brendler, T., Nathan, J., Potter, J. C. Rodgers, K., PDR for Herbal Medicines. New Jersey : Medical Economics Company Inc., 2000

Heber, D., PDR for Herbal Medicines Third Edition, 2004

Lin, C.F., Guo, Y. T., Chen, T. Y., et al., Quercetin-rich guava (Psidium guajava) juice in combination with trehalose reduces autophagy , apoptosis, and pyroptosis formation in the kidney and pancreas of type II diabetic rats. , Molecules, 2016; 21: 3

Laily,N., Kusumaningtyas, R. W., Sukarti, I., Rini, M.R.D.K., The Potency of Guava Psidium Guajava (L) leaves as a functional Immunostimulatory Ingredient. Procedia Chemistry, 2015, 14 : 301-307.

Konig, A., Schzwarzinger, B., Stadlbauer, V., , Lanzerstorfer, P., Iken, M., Schwarzinger, C., Kolb, P., Schwarzinger, S., Morwald, K., Brunner, S., Guava (Psidium guajava) Fruit extract prepared by supercritical CO2 extraction inhibits intestinal glucose resorption in a double blind, randomized clinical study., Nutrients, 2019 : 11

Muller, U. , Stubl V., Schzwarzinger, B., Sandner, G., Iken, M., Himmelsbach, M., Weghuber, J., In vitro and in vivo inhibition of Intestinal glucose transport by guava (Psidium guajava) extracts., Molecular Nutrition and Food Research, 2018 , 62 : 1-11

Naseer,S., Hussain, S., Naeem, N., Pervaiz, M., Rahman, M., The phytochemistry and medicinal value of Psidium guajava (guava). Clinical Phytoscience, 2018, 4 : 1.

Duke, J. A., CRC Handbook of Medicinal Herbs in International Clinical Psychopharmacology., 1990 , 5

Lozoya, X., Reyes-Morales, H., Chavez-Soto, M. A., Martinez-Garcia, M.D.C., Soto-Gonzalez, Y., Doubova, S.V., Intestinal anti-spasmodic effect of phytodrug of Psidium guajava folia in the treatment of acute diarrheic disease. Journal of Ethnopharmacology, 2002, 83(1-2) : 19-24.

Olajide, O.A., Awe, S. O., Makinde, J. M., Pharmacological studies on the leaf of Psidium guajava. Fitoterapia, 1999, 70(1) : 25-31.

WHO., WHO Monographs on Selected Medicinal Plants volume 4, 2009

Irondi, E.A., Aboola, S. O., Oboh, G., Boligon, A.A., Athayde, M.L., Shode, F.O., Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro., Journal of Intercultural Ethnopharmacology., 2016, 5(2) : 122-130.

BPOM RI., Acuan sediaan herbal volume ketujuh edisi pertama., 2012, 7.

Batugal,P., Kaaniah, J., Oliver, J., Medicinal Plants research in Asia Volume 1 : The Framework and project workplans., 2004

Tallei, T. E., Tumilaar, S.G., Niode, N.J., Fatimawali, F., Kepel, B.J., Idroes, R., and Effendi, Y.,Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M pro) & Spike(S) Glycoprotein Inhibitors:A Molecular Docking Study,2020,4: 1–18.

Nguyen, T. T. H. Woo, H.J., Kang, H.K., Nguyen, V.D., Kim, Y.M., Kim, D.W. Ahn, S. A., Xia, Y., Kim, D.,Flavonoid-mediated inhibition of SARS coronavirus 3Clike protease expressed in Pichia pastoris. Biotechnology Letters, 2012, 34(5): 831–838.

Park, J. Y., Yuk, H.J., Ryu, H.W., Lim, S.H., Kim, K.S., Park, K.H., Ryu, Y.B., Lee, W.S., Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors. Journal of Enzyme Inhibition & Medicinal Chemistry, 2017, 32(1): 504–512.

Chairul, C., Jamal, Y. Zainul, Z., Efek Hypoglikemik Ekstrak Alkohol Herba Meniran (Phyllanthus niruri L.) Pada Kelinci Putih Jantan. Berita Biologi, 2000, 5(1): 93-101.

Permata, D.A. and Sayuti, K., Pembuatan Minuman Serbuk Instan Dari Berbagai Bagian Tanaman Meniran (Phyllanthus niruri). Jurnal Teknologi Pertanian Andalas, 2016, 20(1): 44-49.

Harish, R. and Shivanandappa, T., Antioxidant Activity and Hepatoprotective Potential of Phyllanthus niruri. Food chemistry, 2006, 95(2) : 180-185.

Krisyanella, Susilawati, N. and Rivai, H., Pembuatan dan karakterisasi serta penentuan kadar flavonoid dari ekstrak kering herba meniran (Phyllanthus niruri L.), Jurnal Farmasi Higea, 2013, 5(1): 9–19.

Bagalkotkar, G., Sagineedu, S.R., Saad, M.S. and Stanslas, J., Phytochemicals From Phyllanthus niruri Linn. and Their Pharmacological Properties: A Review. Journal of pharmacy and pharmacology, 2006, 58(12) :1559-1570.

Ray, M., Sarkar, S., Rath, S.N. and Rath, M.S.N., Druggability for COVID19–In Silico Discovery Of Potential Drug Compounds Against Nucleocapsid (N) Protein of SARS-CoV-2. Preprint: ChemRxiv.2020

Suryanarayana, L. and Banavath, D., A Review On Identification of Antiviral Potential Medicinal Plant Compounds Against with COVID19. International Journal of Research in Engineering, Science and Management, 2020, 3(3) : 675- 679.

Khaerunnisa, S., Kurniawan, H., Awaluddin, R., Suhartati, S. and Soetjipto, S., Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study. Preprint, doi:10.20944, 2020 : 1-14.

Patel, R., Vanzara, A., Patel, N., Vasava, A., Patil, S. and Rajput, K., Discovery of Fungal Metabolites Bergenin, Quercitrin and Dihydroartemisinin as Potential Inhibitors Against Main Protease of SARS-CoV-2. Preprint: ChemRxiv. 2020.

Mishra, R.C., Kumari, R., Yadav, S. and Yadav, J.P., Antiviral Potential of Phytoligands Against Chymotrypsin-Like Protease of COVID?19 Virus Using Molecular Docking Studies: An Optimistic Approach. Preprint: Nature Research. 2020.

Nallusamy,S., et al., Shortlisting Phytochemicals exhibiting inhibitory activity against major proteins of SARS-CoV-2 through virtual screening., Research Square., 2020

Kamruzzaman, H.M. and Hoq, O., A Review on Ethnomedicinal, Phytochemical and Pharmacological Properties of Phyllanthus niruri. Journal of Medicinal Plants Studies, 2016, 4(6):173-180.

BPOM., Monografi ekstrak tumbuhan obat Indonesia Revisi 1., 2010

Agrawal, R.C.& Pandey, P., Screening of Andrographis Paniculata Extract for antioxidant and genotoxic activities. , International Journal of Research-Granthaalayah., 2019, 7 : 132-142.