HUBUNGAN KADAR INSULIN PUASA DENGAN KADAR GULA DARAH PUASA DAN KENDALI HBA1C PADA KELOMPOK LANSIA
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Abstract
Pendahuluan: Diabetes melitus merupakan penyebab utama morbiditas global, dengan prevalensi yang terus meningkat, terutama pada populasi lansia. Pengukuran gula darah puasa (GDP) dan HbA1c sering digunakan untuk mengevaluasi kontrol glikemik, namun memiliki keterbatasan dalam mencerminkan dinamika sekresi dan sensitivitas insulin. Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara kadar insulin puasa dengan GDP dan HbA1c terutama pada populasi lansia. Metode: Desain studi penelitian ini adalah potong lintang pada 41 lansia di Panti Santa Anna pada November 2023. Analisis statistik menggunakan uji Spearman. Hasil: Analisa korelasi Spearman-rho antara kadar insulin puasa dengan kadar gula darah puasa menunjukkan tidak adanya hubungan bermakna antara kadar insulin puasa dengan kadar gula darah puasa, namun penelusuran secara klinis menunjukkan korelasi positif lemah (p: 0,329, r: 0.156). Kadar insulin puasa terhadap kadar HbA1c juga menunjukkan tidak adanya hubungan bermakna, namun secara klinis berkorelasi positif lemah (p: 0,256, r: 0,182). Kesimpulan: Penelitian ini ingin melihat korelasi positif secara klinis antara kadar insulin puasa dan parameter metabolik diabetes, yang dapat tersamarkan oleh mekanisme kompensasi resistensi insulin serta proses inflamasi dan gangguan metabolik. Penelitian lebih lanjut diperlukan untuk memahami hubungan sebab-akibat antara kedua parameter tersebut dengan kadar insulin puasa secara mendalam sehingga dapat mengoptimalkan target pengobatan dan mencegah komplikasi lebih lanjut.
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