Gambaran estimated Glomerular Filtration Rate pada individu dengan hiperurisemia di Rumah Sakit Sumber Waras periode tahun 2014-2016

Main Article Content

David William
Marina Ludong

Abstract

Hiperurisemia telah dikaitkan dengan tiga macam penyakit ginjal, yaitu nefropati asam urat akut, nefropati asam urat kronis, dan nefrolitiasis asam urat. Suatu survei yang dilakukan di Bandungan, Jawa Tengah atas kerjasama World Health Organization-Community Oriented Program for Control of Rheumatic Diseases (WHO-COPCORD) didapatkan bahwa prevalensi hiperurisemia sebesar 24,3% pada laki-laki dan 11,7% pada wanita. Salah satu tes yang baik untuk menilai fungsi ginjal adalah estimated Glomerular Filtration Rate (eGFR). Tujuan dari penelitian ini adalah untuk mengetahui hiperurisemia sebagai salah satu faktor penyebab gangguan ginjal sehingga dapat menurunkan insiden gagal ginjal akibat nefropati asam uart menurunkan insidens gagal ginjal akibat nefropati asam urat. Penelitian yang digunakan peneliti bersifat deskriptif dengan desain penelitian cross sectional dengan cara pengambilan consecutive non-random sampling. Didapatkan 86 data rekam medis individu dengan hiperurisemia yang melakukan pemeriksaan kreatinin serum di Rumah Sakit Sumber Waras periode tahun 2014-2016. Hasilnya diperoleh 70 orang (81,4%) mengalami penurunan nilai estimated Glomerular Filtration Rate dan 16 orang (18,6%) memiliki nilai estimated Glomerular Filtration Rate normal.

Article Details

Section
Artikel Asli
Author Biography

Marina Ludong, Fakultas Kedokteran Universitas Tarumanagara

Bagian Patologi Klinik

References

So A, Thorens B. Uric acid transport and disease. 2010 Jun 1; 120(6): 1791–1799. Available from: https://www.ncbi. nlm.nih.gov/pmc/articles/PMC2877959/

Mark T, Fahlen M. Uric acid nephropathy. 2015. Available from: http://emedicine. medscape.com/article/244255-overview

Conger JD. Acute uric acid nephropathy. 1990 Jul; 74(4):859-71. Available from: https://www.ncbi.nlm.nih.gov/pubmed/2195258

Chemocare. Hyperuricemia (high uric acid). Avaiable from: http://chemocare.com/ chemotherapy/side-effects/hyperuricemia-high-uric-acid.aspx

National Kidney Foundation. Gout, hyperuricemia, and chronic kidney disease. Available from: https://www.kidney.org/atoz/ content/gout

Lohr JW. Hyperuricemia. 2016. Available from: http://emedicine.medscape.com/article/ 241767-overview#a

Dianati NA. Gout and hyperuricemia. 2015. Available from: http://juke.kedokteran.unila. ac.id/index.php/majority/article/viewFile/555/556

Lugito NPH. Nefropati urat. 2013. Available from: http://www.kalbemed.com/Portals/6/ 06_204Nefropati%20Urat.pdf

National Kidney Foundation. Glomerular filtration rate (GFR). Available from: https://www.kidney.org/atoz/content/gfr.

Kidney Health Australia. Estimated glomerular filtration rate (eGFR). 2015. Available from: http://kidney.org.au/cms_ uploads/docs/estimated-glomerular-filtration-rate-egfr.pdf

Weiner DE, Tighiouart H, Elsayed EF, Griffi th JL, Salem JN, Levey AS. Uric Acid and Incident Kidney Disease in the Community. J Am Soc Nephrol 2008;19: hal. 1204–11.

Domrongkitchaiporn S, Sritara P, Kitiyakara C, Stitchantrakul W, Krittaphol V, et.al.. Risk Factors for Development of Decreased Kidney Function in a Southeast Asian Population: A 12-Year Cohort Study. J Am Soc Nephrol 2005;16: 791 – 9.

Iseki K, Oshiro S, Tozawa M, Iseki C, Ikemiya Y, Takishita S. Signifi cance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects. Hypertens Res 2001;24: 691– 7.

MedlinePlus. Glomerular filtration rate. Available from: https://medlineplus.gov/ ency/article/007305.htm

Michels WM, Grootebdorst DC, Verduijn M, Elliott EG, Dekker FW, Krediet RT. Performance of the cockcroft-gault, mdrd, and new ckd-epi formulas in relation to gfr, age, and body size. Clin J Am Soc Nephrol. 2010 Jun; 5(6): 1003–9.

Obermayr RP, Temml C, Gutjahr G, Knechtelsdorfer M, Oberbauer R, Klauser-Braun R. Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol 2008;19: 2407 – 13.