KORELASI KOMPOSISI LEMAK TUBUH, KOMPOSISI OTOT TUBUH, KEKUATAN GENGGAMAN TANGAN, HEMOGLOBIN, HEMATOKRIT, GULA DARAH, KOLESTEROL, DAN ASAM URAT DENGAN PORFIRIN KULIT PADA KELOMPOK LANJUT USIA
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Abstract
Latar Belakang: Penuaan menyebabkan perubahan fisiologis yang memengaruhi komposisi tubuh, metabolisme, dan kesehatan kulit. Salah satu aspek penting dalam kesehatan kulit adalah mikrobiota, terutama Cutibacterium acnes (C. acnes), yang menghasilkan porfirin sebagai bagian dari metabolismenya. Produksi porfirin dapat dipengaruhi oleh faktor metabolik, seperti komposisi lemak dan otot tubuh, kadar hemoglobin, hematokrit, gula darah, kolesterol, dan asam urat. Telah diketahui bahwa disregulasi metabolik dapat mempengaruhi kadar porfirin kulit, terutama melalui lingkungan mikrobiota kulit. Namun, penelitian mengenai hal tersebut masih belum banyak dilakukan. Tujuan: Penelitian ini bertujuan untuk mengevaluasi hubungan antara komposisi lemak tubuh, komposisi otot tubuh, kekuatan genggaman tangan (KGT), kadar hemoglobin, hematokrit, gula darah puasa, kolesterol, dan asam urat dengan kadar porfirin kulit pada kelompok lanjut usia. Metode: Studi ini menggunakan desain penelitian potong lintang (cross-sectional), melibatkan 22 lansia dengan pengukuran parameter metabolik melalui pemeriksaan laboratorium dan kadar porfirin kulit menggunakan analisa kulit wajah. Analisis korelasi Spearman digunakan untuk mengevaluasi hubungan antara variabel independen dengan kadar porfirin kulit. Hasil dan Pembahasan: Kadar gula darah puasa dan kadar asam urat menunjukkan korelasi negatif sedang yang signifikan terhadap kadar porfirin kulit (p < 0,05). Sementara itu, variabel lain seperti komposisi tubuh, kekuatan genggaman tangan, hemoglobin, hematokrit, dan kolesterol tidak menunjukkan hubungan yang signifikan. Kesimpulan: Disregulasi metabolik dapat mempengaruhi lingkungan mikrobiota kulit yang mempengaruhi kadar porfirin kulit.
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